![]() the mortality of smallpox could be 20 to 50% among Europeans but entire tribes of North American Indians were eliminated by the same viral infection) ( 1, 2). In these disease outbreaks, mortality among infected Europeans was significant but deaths were even greater proportionately among affected Native Americans (e.g. ![]() ![]() Much of this was associated with respiratory tract infections including smallpox, tuberculosis, measles, and influenza ( 1, 2). In addition to deliberate killings and wars, Native Americans died in massive numbers from infections endemic among Europeans. Beginning in the 15 th century, interactions with Europeans resulted in a cataclysmic decrease in the population of peoples indigenous to the Americas.
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